Serum Cytokine Reactions during Pregnancy in Healthy Mares

The aim of the research was to determine differences in IL-1ß, IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α and IL-1ra blood concentrations pregnant non-pregnant healthy mares. mares were divided into two groups: (n = 18; age 6.11 ± 2.25 years); 6; 5.67 1.75 years). Blood samples collected from all 24) three times every month, then group subgroups based on pregnancy (1st 6)—6th, 7th, 8th; 2nd 6)—7th, 8th, 9th; 3rd 6)—8th, 9th, 10th month pregnancy). higher than group, whereas only concentration lower groups. Serum proinflammatory cytokines such as IL-1 β, IFN-γ greater at start trimester, whereas, IL-17 started rise latter months third trimester. IL-10 decrease after 6th pregnancy. In cytokine levels stable during whole study. mares, change ratio between Th1 (IL-1, TNF-α) Th2 (e.g., IL-13) occurs profile may be useful future for monitoring pregnancies; however, more is needed especially miscarriage